两个巨大的red flag，第一是没有对照组，第二是这一句话：At Day 14, 64.5 percent (n=129/200) of patients in the
5-day treatment group and 53.8 percent (n=106/197) of patients in the 10-day
treatment group achieved clinical recovery.

用药10天的治愈率更低？！是否说明药的作用是反的？

个人仍然持强烈怀疑态度，等NIH实验的结果，从这个实验结果看不出药有用。

nyc15 发表于 4/29/2020 8:58:13 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808399#83808399][img][/img][/url]

划重点: 没有control group。 看得懂英文的好好读读

The main concern, they say, stems from the fact that the Gilead trial expected to read out this week, which was conducted among patients with severe disease, lacks a control group — that is, patients who are randomly assigned to receive the best treatment available, but not remdesivir. As designed, the only randomization is the duration of treatment: either five days or 10 days of drug. Without a true control group of patients, many experts say, it will be difficult to determine whether remdesivir is effective.

“The overall study itself has little or no scientific value since all patients are receiving the drug,” said Steven Nissen, the chief academic officer at the Cleveland Clinic and lead investigator of many trials for heart drugs that have been approved by the Food and Drug Administration.

“The study, as designed, is essentially useless and cannot be used by the FDA for consideration of remdesivir for approval to treat coronavirus,” Nissen said.

Peter Bach, director of the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center, called the situation “frustrating.”

“For them to run the trial in severe but not include a control group, it’s just such a waste,” Bach said.
cannie 发表于 4/29/2020 9:34:27 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808675#83808675][img][/img][/url]

回复 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&&fid=398&postid=83809126#83809126]48楼noshock的帖子[/url]
我是从Gilead半路上扩大实验规模和改变评价标准的时候开始怀疑的，内行都知道这意味着什么。。。在这以前我也错误地认为瑞德西韦是特效药。

nyc15 发表于 4/29/2020 10:37:18 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809170#83809170][img][/img][/url]

Fauci said he was told data from the trial showed a “clear cut positive effect in diminishing time to recover.”
怎么能理解成
FAUCI: DATA SHOWS REMDESIVIR `CLEAR CUT' POSITIVE EFFECT

violabb 发表于 4/29/2020 12:35:14 PM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83810542#83810542][img][/img][/url]

无语 没有对照组
哪门子的有效
miss6161 发表于 4/29/2020 2:07:29 PM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83811951#83811951][img][/img][/url]

新的updates：



initium 发表于 4/29/2020 2:03:59 PM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83811900#83811900][img][/img][/url]

NIAID press release confirms Fauci comments in WH press pool:

Median time to recovery (reached statistical significance):
- 11 days for remdesivir group
- 15 days for placebo group

Mortality rate (not stat. sig.):
- 8% for remdesivir
- 11% for placebo
Jordan 发表于 4/29/2020 2:36:42 PM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83812399#83812399][img][/img][/url]