google半天找到原作者justin Rhodes, 以及他发表的几篇文章.正在研究中...

Rhodes J.S., van Praag H., Jeffrey S., Girard I., Mitchell G.S., Garland T., Jr., Gage F.H. (2003) Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behavioral Neuroscience, 117:1006-1016.

Rhodes J.S., Garland T., Jr., Gammie S.C. (2003) Patterns of brain activity associated with variation in voluntary wheel-running behavior. Behavioral Neuroscience, 117:1243-1256.

Rhodes J.S., Garland T., Jr. (2003) Differential sensitivity to acute administration of Ritalin, apomorphine, SCH 23390, but not raclopride in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology, 167:242-250.

Johnson R.A., Rhodes J.S., Jeffrey S.L., Garland T., Jr., Mitchell G.S. (2003) Hippocampal brain-derived neurotrophic factor but not neurotrophin-3 increases more in mice selected for increased voluntary wheel running. Neuroscience, 121:1-7.

Gammie S.C., Hasen N.S., Rhodes J.S., Girard I., Garland T., Jr. (2003) Predatory aggression, but not maternal or intermale aggression, is associated with high voluntary wheel-running behavior in mice. Hormones and Behavior, 44:209-221.

Note: (by Oceanwhite)

这篇文章加精是因为lurenyi对lz转来的<运动过度脑子会变笨> 一文中的内容出处做了很详尽的考证, 分享了查到的原文(上一楼), 并摘录了其主要结论.(本楼和下一楼)介绍给大家.

我想向大家提倡lurenyi的这种严谨的态度. 人体是一个很复杂的系统, 很多奥秘还不为人知. 有很多网上的文章对某些研究成果做"只言片语"的摘录, 可能目的只是为了吸引眼球,甚至是有商业目的. 读这些文章,对它们的观点一定要有选择地接受,对某些观点也应该加以考证,这才是对读者和对自己负责的表现. 凡是花了时间精力认真考证,分析,并分享成果的, 我们也一定会appreciate.

通常认为多运动可以促进BDNF(brain derived neurotrophic factor)的分泌,促进海马体神经的生长,从而促进老鼠学习能力的加强.但是作者的研究却打破了这种必然联系,在特殊培育的S系和普通C老鼠之间对比发现S和C跑步的老鼠比不跑的BDNF以及神经生长都加强了,C老鼠学习能力通过跑步得到了提高,可是S老鼠的学习能力没有通过跑步提高.还是看看作者自己是怎么说的吧:

The present study confirms that access to a running wheel increases hippocampal BDNF concentration (Neeper et al., 1995), hippocampal neurogenesis (van Praag, Kempermann, & Gage, 1999), and spatial learning (Anderson et al., 2000) in normal rodents. The study also confirms that there is a strong positive correlation between running distance and neurogenesis in normal mice (Allen et al., 2001). Results for S mice provide the first evidence that there may be a limit to exercise-induced neurogenesis because the correlation between running distance and neurogenesis was lost in S mice as a result of a possible ceiling effect (Figure 3D). Another noteworthy finding was that despite extraordinarily high levels of exercise, and high levels of exercise-induced neurogenesis in S mice, spatial learning was not improved. The possibility that neurogenesis represents a mechanism for learning is exciting, but future work will be needed to resolve this issue. In the meantime, we suggest it is useful to consider alternative possibilities regarding the functional significance of exercise-induced neurogenesis, such as a role in locomotor performance.

[此贴子已经被oceanwhite于2005-10-17 20:44:26编辑过]

忘了说了,喜欢跑步的S老鼠平均每天跑11.5公里(个体2-18公里不等)

而越跑越聪明的普通老鼠C则每天跑3.6公里(个体1-6公里不等,每天跑6公里的比每天不跑或者跑的少的学的快)

筒子们那,相比小老鼠我们的问题不是跑得太多而是跑得太少哇...

[此贴子已经被作者于2005-10-17 16:45:06编辑过]