感谢楼主的科普文，乙肝疫苗真的是救了太多人，而且现在母婴传播都可以阻断了，也降低了很多乙肝病毒携带者的歧视问题。因为我小时候打乙肝疫苗的时候估计是第一代，所以会出现抗体滴度不够补打的现象。现在的新生儿是不是打完三针就可以终身免疫呢？还是说也是要经常做个血检检查抗体浓度？

gigivivi 发表于 2024-08-29 09:18

找到这篇论文 https://pubmed.ncbi.nlm.nih.gov/29641290/

按这篇论文的说法，95%健康的新生儿接受三针及时的乙肝疫苗能产生有效的保护抗体。

Immunization starting with a first dose within 24 hours of birth is recommended10 due to the high risk (90%) of developing lifelong, chronic HBV infection in neonates, with the risk decreasing to approximately 20% to 30% by 1 to 5 years of age.11 Approximately 95% of immunocompetent infants vaccinated with 3 doses of HBV vaccine demonstrate seroprotective anti-HBs levels (≥10 mIU/mL), with levels >100 mIU/mL considered to provide an enduring response.7 Following primary immunization, protective antibody levels may decrease to low or undetectable levels.6,7

但是有些人需要打加强针。

The most recent WHO hepatitis B vaccine position paper posits that studies assessing life-long protection following HBV immunization are still needed, such that certain sub-populations may require a vaccine booster dose.

我的理解是大部分新生儿准时打了三针就可以终身免疫了，但是并不是对所有人都成立，所以如果有特别的理由，比如家族里有人是乙肝携带者，那保险起见可以去查查乙肝抗体的滴度，看是否需要补打加强针。

哇太感谢了MM那么详细的回复！！确实反正做个血检也不费什么事。