这是重症的。这个出了数据的是只收重症的。 用20%重症率来算， 那么 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213]人民的希望[/url]推广后死亡率是20%*8%=1.6%。 这还是假设轻症不用药的情况。
relay 发表于 4/29/2020 10:17:16 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809018#83809018][img][/img][/url]
这些五毛，要么看不懂英文，要么装瞎。非蠢即坏。 看他们跳，一边觉得他们真是可悲，一边又觉得好好笑。
relay 发表于 4/29/2020 10:05:06 AM
本来就是应对伊波拉的药，指望它完全对症新冠从来就不现实。短期内没别的药，先拉上顶着而已，好歹比用于应对艾滋病的克利芝感觉离新冠近些
galezhang 发表于 4/29/2020 9:02:58 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808429#83808429][img][/img][/url]
This is for those hospitalized (住院的, 不一定插管的). I still feel this fatality rate is kind of high for those hospitalized.
atomicmass 发表于 4/29/2020 10:22:17 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809052#83809052][img][/img][/url]
两个巨大的red flag，第一是没有对照组，第二是这一句话：At Day 14, 64.5 percent (n=129/200) of patients in the
5-day treatment group and 53.8 percent (n=106/197) of patients in the 10-day
treatment group achieved clinical recovery.
用药10天的治愈率更低？！是否说明药的作用是反的？
个人仍然持强烈怀疑态度，等NIH实验的结果，从这个实验结果看不出药有用。
nyc15 发表于 4/29/2020 8:58:13 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808399#83808399][img][/img][/url]
回复 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&&fid=398&postid=83809115#83809115]47楼relay的帖子[/url]
你要仔细看报告，进入试验的一个要求是开始给药的时候还没有上呼吸机！所以这根本不是最严重病人的数据，真正严重的病人还没来得及进医院就爆发性呼吸衰竭憋死在家里了。
nyc15 发表于 4/29/2020 10:39:11 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809191#83809191][img][/img][/url]
回复 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&&fid=398&postid=83809115#83809115]47楼relay的帖子[/url]
你要仔细看报告，进入试验的一个要求是开始给药的时候还没有上呼吸机！所以这根本不是最严重病人的数据，真正严重的病人还没来得及进医院就爆发性呼吸衰竭憋死在家里了。
nyc15 发表于 4/29/2020 10:39:11 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809191#83809191][img][/img][/url]
还有那个无底线维护WHO的盖子。今早看到他的一个采访，当记者问到疫情对美国经济和社会的灾难性影响，他都抑制不住得意的笑出声，起鸡皮疙瘩。
fufusix 发表于 4/29/2020 9:22:50 AM [url=http://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808590#83808590][/url]
划重点: 没有control group。 看得懂英文的好好读读
The main concern, they say, stems from the fact that the Gilead trial expected to read out this week, which was conducted among patients with severe disease, lacks a control group — that is, patients who are randomly assigned to receive the best treatment available, but not remdesivir. As designed, the only randomization is the duration of treatment: either five days or 10 days of drug. Without a true control group of patients, many experts say, it will be difficult to determine whether remdesivir is effective.
“The overall study itself has little or no scientific value since all patients are receiving the drug,” said Steven Nissen, the chief academic officer at the Cleveland Clinic and lead investigator of many trials for heart drugs that have been approved by the Food and Drug Administration.
“The study, as designed, is essentially useless and cannot be used by the FDA for consideration of remdesivir for approval to treat coronavirus,” Nissen said.
Peter Bach, director of the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center, called the situation “frustrating.”
“For them to run the trial in severe but not include a control group, it’s just such a waste,” Bach said.
cannie 发表于 4/29/2020 9:34:27 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808675#83808675][img][/img][/url]
NIN的是双盲的吧。这个randomized的实验感觉只是不想浪费数据，既然有患者在用药，那就统计统计，起码得出用药5天和10天治疗效果无差别的结果，也没打算用这个试验的结果去跟FDA申请吧
minijing 发表于 4/29/2020 10:52:19 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809347#83809347][img][/img][/url]
回复 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&&fid=398&postid=83809126#83809126]48楼noshock的帖子[/url]
我是从Gilead半路上扩大实验规模和改变评价标准的时候开始怀疑的，内行都知道这意味着什么。。。在这以前我也错误地认为瑞德西韦是特效药。
nyc15 发表于 4/29/2020 10:37:18 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809170#83809170][img][/img][/url]
希望五毛們能有些良心。
你們可以大反“人民的希望”這個名字，
停止破壞這救命的藥吧。
cfc006 发表于 4/29/2020 10:30:46 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809106#83809106][img][/img][/url]
这名字又不是美国人起的。
Ruth 发表于 4/29/2020 11:02:05 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809470#83809470][img][/img][/url]
这名字又不是美国人起的。
Ruth 发表于 4/29/2020 11:02:05 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83809470#83809470][img][/img][/url]