没有对照组，研究个屁啊？！
这是有机构在炒作这只股票而已。


pig0019 发表于 4/29/2020 9:11:14 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808506#83808506][img][/img][/url]

看看WHO武汉卫生组织上周的表演，是不是觉得无比丑恶？！
Absurdist 发表于 4/29/2020 9:13:31 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808524#83808524][img][/img][/url]

两个巨大的red flag，第一是没有对照组，第二是这一句话：At Day 14, 64.5 percent (n=129/200) of patients in the5-day treatment group and 53.8 percent (n=106/197) of patients in the 10-daytreatment group achieved clinical recovery.用药10天的治愈率更低？！是否说明药的作用是反的？个人仍然持强烈怀疑态度，等NIH实验的结果，从这个实验结果看不出药有用。
nyc15 发表于 4/29/2020 8:58:13 AM

本来就是应对伊波拉的药，指望它完全对症新冠从来就不现实。短期内没别的药，先拉上顶着而已，好歹比用于应对艾滋病的克利芝感觉离新冠近些


galezhang 发表于 4/29/2020 9:02:58 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808429#83808429][img][/img][/url]

划重点: 没有control group。 看得懂英文的好好读读

The main concern, they say, stems from the fact that the Gilead trial expected to read out this week, which was conducted among patients with severe disease, lacks a control group — that is, patients who are randomly assigned to receive the best treatment available, but not remdesivir. As designed, the only randomization is the duration of treatment: either five days or 10 days of drug. Without a true control group of patients, many experts say, it will be difficult to determine whether remdesivir is effective.

“The overall study itself has little or no scientific value since all patients are receiving the drug,” said Steven Nissen, the chief academic officer at the Cleveland Clinic and lead investigator of many trials for heart drugs that have been approved by the Food and Drug Administration.

“The study, as designed, is essentially useless and cannot be used by the FDA for consideration of remdesivir for approval to treat coronavirus,” Nissen said.

Peter Bach, director of the Center for Health Policy and Outcomes at Memorial Sloan Kettering Cancer Center, called the situation “frustrating.”

“For them to run the trial in severe but not include a control group, it’s just such a waste,” Bach said.
cannie 发表于 4/29/2020 9:34:27 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808675#83808675][img][/img][/url]

两个巨大的red flag，第一是没有对照组，第二是这一句话：At Day 14, 64.5 percent (n=129/200) of patients in the
5-day treatment group and 53.8 percent (n=106/197) of patients in the 10-day
treatment group achieved clinical recovery.

用药10天的治愈率更低？！是否说明药的作用是反的？

个人仍然持强烈怀疑态度，等NIH实验的结果，从这个实验结果看不出药有用。

nyc15 发表于 4/29/2020 8:58:13 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808399#83808399][img][/img][/url]

别装了，你是对美国所有东西不看好
stainlessbelief 发表于 4/29/2020 9:09:23 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808489#83808489][img][/img][/url]

别装了，你是对美国所有东西不看好
stainlessbelief 发表于 4/29/2020 9:09:23 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808489#83808489][img][/img][/url]

无毛一只，早屏蔽了

lishu2 发表于 4/29/2020 9:51:46 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808837#83808837][img][/img][/url]

quick note from an analyst:
"This is earlier than expected
Most important study we are aware of. Has a placebo.
This is the trial run by the govt – NOT the GILD trial we were expecting results out today or tomorrow.
This was NOT just in severe patients. This is MODERATE and severe
It hit the primary endpoint which means it hit the efficacy end point which for dummies means it works. "
Caffeine 发表于 4/29/2020 8:48:37 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808345#83808345][img][/img][/url]

回复 [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808675#83808675]26楼cannie的帖子[/url]

公布了两个trial的结果。Gilead自己的没有placebo。NIH的那个有placebo。
nitride 发表于 4/29/2020 10:02:01 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808901#83808901][img][/img][/url]

"The overall mortality rates in the five-day and 10-day groups were 8.0% (n=16/200) and 10.7% (n=21/197), respectively." 这个?
atomicmass 发表于 2020-04-29 10:12

线性外推的话就是说不用药的死亡率是5.4%

"The overall mortality rates in the five-day and 10-day groups were 8.0% (n=16/200) and 10.7% (n=21/197), respectively." 这个?
atomicmass 发表于 4/29/2020 10:12:51 AM [url=https://forums.huaren.us/showtopic.aspx?topicid=2541213&postid=83808988#83808988][img][/img][/url]