赞靠谱回复！不止高血糖，skip meal和胰岛素过量导致的低血糖也要防备。

我当年在graduate school一直研究胰岛，后来不在这个领域了但一直断断续续有关注。最近几年有一些基于干细胞的研究，诱导出的胰岛从形态和功能上看非常promising，希望技术能早日成熟到可以进行胰岛移植。

看这个

https://www.medscape.com/viewarticle/977615

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COMMENTARY

A Brighter Future for Those With Type 1 Diabetes

Aaron J. Kowalski, PhD; Mark Harmel, MPH, CDCES

DISCLOSURES August 02, 2022

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This transcript has been edited for clarity.

What an amazing time it is to be living with type 1 diabetes in 2022 and see the evolution of diabetes technology. I say this both personally and professionally. My brother was diagnosed with type 1 in 1977 in the days of urine glucose testing and animal insulin. I was diagnosed in 1984, the advent of blood sugar testing. Here we are today in 2022, both wearing hybrid closed-loop systems.

I'm so proud of the role that JDRF played. I was fortunate to be a scientist on the team in 2005 that launched what we called the JDRF Artificial Pancreas Project. Since then, we've funded over $100 million in research. We focused on continuous glucose monitors — something that, again, my brother and I, and now hundreds of thousands of people around the world, are benefiting from. We funded a pivotal trial that showed the effectiveness of CGM [continuous glucose monitoring] devices and was published in The New England Journal of Medicine. Then we focused on closing the loop.

Back then, people said, "Oh, you can't do this. You can't deliver insulin subcutaneously. You might kill people. The sensors aren't accurate enough." We did the research. We showed that it could be done. Today, in 2022, we have three commercially available systems (Medtronic, Insulet, and Tandem), and we have what we call do-it-yourself systems that people have put together, built their own algorithms, that allow people to control their diabetes off their cell phones.

I wear two hats. I wear the hat of a scientist in the diabetes field and a person with diabetes. The scientists and clinical people often think of glycemia, and we know that these hybrid closed-loop systems work there. They improve glycemia, more time in range, better A1c, less hypoglycemia.

It works across the spectrum. It works for people who have tight control and it works for people who struggle with their diabetes. We've seen A1cs come down from 10's into the 7's, and we see people who have 6.5's maintain those A1cs with less hypoglycemia.

The glycemic benefits are profound, but as a person with diabetes, it's more than just glycemia. We have to appreciate that there's more to life than diabetes. Hybrid closed-loop systems help improve our quality of life, whether it's sleeping through the night, fewer alarms, or less anxiety about lows.

The life around diabetes is not just the person. It's my wife, my kids, and my parents. This ecosystem that evolves around and supports the person with diabetes benefits from these technologies as well. I often use a teeter-totter analogy for glycemia and quality of life: The beauty of these hybrid systems is that they're helping on both fronts.

I often joke that you'll never find somebody who doesn't have diabetes who wears an insulin pump. By that, I mean that people with diabetes wear pumps because they benefit their life, their health, and their quality of life. It's not like somebody out in the world who doesn't have diabetes puts a pump on for kicks.

That's an important distinction because, ultimately, the goal of JDRF is to drive to a future where we don't have to wear pumps, but instead, we get all the benefits of better glycemic control, lifting the burden of diabetes management off our shoulders through cellular- or immunotherapies. We're seeing amazing progress on that front, whether it's stem cell–derived islets, immunoregulatory cells, or different drugs that might reduce the burden of the immune response of type 1 diabetes.

I think the future is incredibly bright for a day where we can take our pumps off and move to endogenous insulin production again in type 1 people.

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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.

Cite this: A Brighter Future for Those With Type 1 Diabetes - Medscape - Aug 02, 2022.

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这个时刻提醒我们，健康胜过一切，加油

一上来就严重到每天注射胰岛素了？吃药不行吗，还能逆转吗

zlf 发表于 2021-11-21 19:38

呼唤common sense ，如果不懂至少发言之前Google 一下。不过如果灌水另说

私以为I型糖尿病是比较残酷的一种病，正值青春年华享受人生的时候，却不能和小伙伴一起浪吃浪喝，还要面对各种complication，经常出入医院，不过，听说目前有一种移植手术可以治疗I型，具体不清楚。

我家一个娃年初打的Covid疫苗，这半年多瘦了好几磅

以为孩子长个子，或者天热胃口不太好，或者肠胃不太好。看了这个帖子，也担心会不会是糖尿病了 哎

回复 20楼SAT的帖子

糖尿病一个症状就是体重减轻。

糖尿病就是不能在血液里有稳定的血糖，低的时候就会消耗肌肉和脂肪？

我飞呀飞 发表于 2021-11-21 19:50

大人掉秤也是糖尿病吗？自打东岸被臭虫咬后，瘦了不到10磅呀

所以問題來了，為什麼免疫系統會突然攻擊胰島細胞呢。

活了十幾年都沒有事，到底是什麼近期外源因素造成的呢。

arcueid 发表于 2022-08-31 15:52

远在covid 出来之前， 当然也是在covid 疫苗出来之前，一型糖尿病的病程就很清楚了， 就是在青少年时期发病。

不止疫苗，病毒感染也会引起一型糖尿病。本身就是免疫系统引起的。希望孩子只是暂时的。免疫系统工作很复杂，能自己修复也是可能的，楼主也不要太难受了。

嗯，CGM加胰岛素泵

主要是防低血糖

尤其是凌晨睡觉时

以前没有CGM的时候

父母都是得轮流每隔几小时扎手指测血糖

防止低血糖

非常辛苦

现在有CGM了

手机设置好低血糖报警

可以睡整觉了

oqo 发表于 2021-11-21 22:33

高血糖的人也会低血糖吗

美国一型糖尿病真的非常多，算常见病，像中国这种亚洲国家就非常少，到底是什么原因呢？

big bless!!!!!

高血糖的人也会低血糖吗

kawai 发表于 2022-08-31 19:42

用胰岛素的要特别注意防范低血糖。我爸有认识的人去郊区骑车，被发现时已经走了，根据他当时姿态，应该是意识到不好，下车，车座下面绑着一包硬糖，袋子已经扯开，估计没来得及吃到，又没有人路过救助。

我还在诊所停车场看到过抢救，我从诊所出来，我的车被消防车挡住了，就在那里等，听到家属说，就是逛街的时候忽然不行了，送到这个诊所，诊所没有急救，打了911，消防队赶过来立刻挂了糖水，病人就坐在自己车副驾上，我出来的时候已经挂上了，我眼看着病人脸色从灰白恢复了生气，等他清醒了，消防队挪车，还跟我道歉来着，我当然说没事了。

一型用胰岛素的，最好带监测。

你是谁啊？你是专家吗？我还没看到哪个疾病是靠年龄来区别的，你说错的地方，还不能别人纠正？

这公告论坛还只能专家讨论这个？这么常识性的事情你以为就专家才知道？只能说你孤陋寡闻

springtree2 发表于 2022-08-31 17:12

我说错了？你怎么这么确定？你没看到就说明别人错吗？一型糖尿病怎么来的还真没有定论。即使医生通过症状确认一型，也不一定就是一型，即使是一型也不能确定是基因引起的。

我说错了？你怎么这么确定？你没看到就说明别人错吗？一型糖尿病怎么来的还真没有定论。即使医生通过症状确认一型，也不一定就是一型，即使是一型也不能确定是基因引起的。

乘物以游心 发表于 2022-08-31 20:18

从楼主的孩子的年龄，你一口咬定绝对不是一型糖尿病，你还觉得自己没错？有点common sense好吗？还说我没看到什么就觉得别人错？我看到一堆十几岁的孩子被诊断一型糖尿病，我看到你说的14岁了，绝对不是type 1，这句话大错特错

你扯其他的干嘛？我就是回的你说的这句话：14岁了，绝对不是type I。我说怎么能靠年龄来说绝对不是type 1，你就攻击我，问我是谁，我是不是专家？

你现在扯什么一型糖尿病怎么来的还真没有定论。即使医生通过症状确认一型，也不一定就是一型，即使是一型也不能确定是基因引起的（我前面和你讨论过这些吗？）

一型糖尿病的发病原因当然没有定论，绝大部分疾病都不知道发病病因，对于病因都有好几个学说，对于一型糖尿病，基因导致的这个学说是获得医学界最多的认可而已，但医学界并不认为基因是唯一的可能性。另外还是提醒你有点common sense好吧，医生会通过症状确认一型？这是什么医生？有没有license？江湖游医？会靠症状来确定是不是一型？说出来很搞笑好吧

请不要东扯西扯，我就是回的你这句话14岁了，绝对不是type I，请解释你这句话是对的，如果你能解释，我给你道歉，如果你不能解释你说的是对的，东扯西扯，不要回我的帖子了，我没这功夫和你打嘴皮子，我不愿意和一个在论坛上说错误的东西，别人提醒以后，就攻击人，而且死揪着不放的人交流。

大家可能会好奇孩子的身高体重平时运动习惯饮食习惯，以及家族糖尿病史

楼主什么都不说，就说打完疫苗不久发现糖尿病，搞得好像打疫苗跟糖尿病产生了因果关系一样

最后送上bless

Leike 发表于 2021-11-21 19:38

COVID疫苗导致糖尿病。随便用Duckduck或者 Brave搜索一下，出来好多这方面的文章：

https://pubmed.ncbi.nlm.nih.gov/35088548/

https://pubmed.ncbi.nlm.nih.gov/35135929/

https://pubmed.ncbi.nlm.nih.gov/35220662/